"At first, his method was to extract streptococcal abscess, that is, benign pus, and then culture it with pure cells.

The last bacterial solution is Dr. Corey''s original "cancer vaccine."

"Awesome!" Yunlan was surprised.

Cancer vaccine, these four words alone sound particularly powerful.

"Ha ha." Wu Mian smiled. "When I saw here, I began to look for information. I realized that Dr. Collie didn''t fall in love with the girl Dahir."

"Why?"

"Because little John Rockefeller sponsored Dr. Collie''s research. I wondered why Rockefeller''s heirs would be interested in cancer vaccine. So I found some information and found that Dahir was little John''s sister."

"...." Yun Lan was at a loss. "Does this have anything to do with immunotherapy?"

"This is a very cruel reality." Wu Mian did not continue this line. "Dr. Collie felt that he had found the wealth code. I can imagine his excitement at that time. In April 1891, Zola, a desperate patient, became a volunteer and was ready to try a new treatment."

"Because it was an experimental treatment, it was carried out in an apartment. Dr. Collie injected Zola with Streptococcus haemolyticus B. according to records, Zola was half dead. But two weeks later, the neck tumor disappeared and he recovered."

"Er..." Yunlan felt that it was beyond his understanding.

Is Streptococcus haemolyticus B so effective?

It''s so effective!

Can I have a try? If the Affiliated Hospital of Nanfang university can''t, my senior brother bought himself some laboratories overseas.

When Wu Mian said this, Yun Lan was greatly moved. But then he "woke up" and lost his smile.

This was done more than a hundred years ago.

"After that, Zola lived healthily for another 8 years. This experiment gave Corey hope.

Within two years of Zola''s recovery, Collie carried out "infection treatment" for a total of 12 patients

"But the effect is not satisfactory. I think the data recorded by Dr. Collie are full of water. Of the 12 patients, 6 tumors have been relieved, 2 have recovered and 2 have died due to infection."

"Why is there water?" Yun LAN asked.

"For the treatment of advanced tumors, this probability can not be reached even by modern science and technology. Would Dr. Collie be dissatisfied 130 years ago? I don''t think so. Moreover, I repeated the test on mice. Unfortunately, 97.8% of mice injected with B hemolytic streptococcus will die of infection."

“……”

"After repeated experiments, the Department replaced the original live bacteria with two kinds of inactivated bacteria, namely Streptococcus pyogenes and Serratia marcescens.

Among them, the latter can enhance the effectiveness of the former, so that the injection can cause high fever. At the same time, inactivated bacteria also greatly reduce the risk of infection and death of patients. This bacterial hybrid vaccine is the modern so-called "Cori toxin"

"At that time, the pharmaceutical company Parker Davis cooperated with Corey to provide Corey toxin preparations for doctors from 1899 to 1951."

"Modern medicine is evidence-based medicine. Dr. Collie thinks it is useless to have an effect. He wants to find a clear chain of evidence to convince others. But after World War II, when Collie tried to find evidence, cancer radiotherapy began to become popular.

Although radiotherapy has always been regarded as "killing eight hundred enemies and losing one thousand", it has a visible curative effect on almost every patient. "

"From the beginning of chemotherapy and radiotherapy, Dr. Collie was considered a civil quack, but he had a daughter. His daughter has been collecting evidence. Until later, it is the modern version of immunotherapy as you know."

"The process is so complicated."

Yunlan didn''t expect that immunotherapy should involve the efforts of the previous two generations.

"Well, the principle has not been fully understood so far. In memory of the" father of tumor immunotherapy ", the highest honor of tumor immunology was also named" William Collie Award ".

It is worth mentioning that Chen Lieping, a Chinese oncologist, won the 2014 Cori Award for discovering the pathogenesis of immune tolerant cancer. "

"In other words, in addition to tumor immunity, there is also a possibility of oncolytic virus in the current situation of the oldest patient in our shelter hospital."

"If it is true, then COVID-19 may have the potential to become oncolytic virus."

"The literature report of tumor regression after infection with influenza virus was first reported in 1904. Dock first reported a case of remission of leukemia in a 42 year old female leukemia patient after infection with influenza virus."

"In 1912, the Italian doctor depace reported a case in which the tumor spontaneously subsided and shrunk after injection of rabies vaccine in patients with advanced cervical cancer. The woman with cervical cancer was bitten by a dog and vaccinated with rabies vaccine. After that, cervical cancer began to shrink. Everyone thought it was a miracle."

"Er... Miss Wu, I''ve heard of it."

"The success of genetically engineered oncolytic virus in tumor treatment was first seen in 1991." Wu Mian ignored Yunlan''s words and continued, "so far, the most successful oncolytic virus is type 5 recombinant human adenovirus for the treatment of esophageal cancer."

"Miss Wu, do you mean that the new pneumonia virus has the potential to treat cancer?" Yun LAN asked in amazement.

"I just gossip with you." Wu Mian smiled. "The new pneumonia virus is a typical ''wild'' virus. It happens to have an effect on a cancer patient, but there is no way to promote it on a large scale. Therefore, I can only think that this cancer patient is lucky."

Lucky

As a doctor of medicine, Yunlan is hard to accept such words.

But Wu Mian and teacher Wu have explained in detail. Yunlan doesn''t know how to refute for a moment.

"This patient is for you to record the changes of swollen lymph nodes in his neck every day. You can tell him that his cancer is getting better. I think this is good news for the shelter hospital."

"Mr. Wu, what if patients pass it on to each other and say that the new pneumonia virus can treat cancer, leading some cancer patients to take the initiative to contact the source of infection?"

"There''s no way." Wu Mian said positively. "Generally, they do this with the attitude of dead horses as living horse doctors. It''s difficult for similar patients to reason with them. I met a patient who took Stellera chamaejasme orally. The dose exceeded about 10 times the dose of traditional Chinese medicine, directly lost his immunity and led to the death of the patient."

“……”

"Why don''t you explain to the patient, or go to your elder martial brother Lu. Now you need good news, and this is a good news."